Recent Advances in the Development of Polymeric Floating Biomaterials for Helicobacter Pylori Therapy: Current Status and Future Directions

Abstract

Helicobacter pylori (H. pylori) infection is a common global health problem linked to peptic ulcers, gastric cancer, and other digestive problems. Current H. pylori eradication therapy must address issues such as antibiotic resistance, poor patient compliance, low stomach pH, and insufficient medication concentration at the infection site. With an emphasis on the present state and potential future directions in this developing field, this review attempts to give a broad overview of recent developments in the creation of such biomaterials for H. pylori therapy. This review examines the benefits of microballoon-based drug administration, utilizes the situation of H. pylori therapy, and covers a number of formulation and evaluation techniques for microballoons. Additionally, it discusses current studies and clinical trials using microballoon drug delivery techniques to treat H. pylori. Microballoons have the potential to improve drug delivery, reduce dose frequency, increase drug stability, and improve drug targeting. The assessment of challenges and opportunities in this burgeoning field provides insights into the evolving landscape of biomaterial-based H. pylori management, offering a roadmap for forthcoming research and clinical implementation.