Advances in Systems Science and Applications 2020-10-09T09:44:22+00:00 Natalya Pavlova Open Journal Systems <p><strong><em>Advances in Systems Science and Applications </em></strong><strong>(<em>ASSA</em>) </strong>is an international peer-reviewed open-source online academic journal. Its&nbsp;scope covers all major aspects of systems (and processes) analysis, modeling, simulation, and control, ranging from theoretical and methodological developments to a large variety of application areas. Survey articles and innovative results are also welcome.</p> <p>ASSA is aimed at the audience of scientists, engineers and researchers working in the framework of these problems. ASSA should be a platform on which researchers will be able to communicate and discuss both their specialized issues and interdisciplinary problems of systems analysis and its applications in science and industry, including data science, artificial intelligence, material science, manufacturing, transportation, power and energy, ecology, corporate management, public&nbsp;governance, finance, and many others.</p> Mathematical Modeling of Antitumor Viral Vaccine Therapy: From the Experiment to the Clinic 2020-10-09T09:44:22+00:00 Nina A. Babushkina Ekaterina A. Kuzina <p>The paper presents the model developed to identify efficient strategies of antitumor viral vaccine introduction. These strategies are able to produce complete suppression of the tumor growth. The model was developed in MatLab-Simulink. Three efficient strategies of viral vaccine introduction were produced. It was found that the choice of the strategy depends on the tumor size at the start of the treatment, and the range of the tumor sizes for each of the strategies was identified. For the small tumors, elimination of the tumor can be achieved through single-shot vaccine administration in dosages that lead to the death of tumor cells caused directly by the virus. For the big tumors that are within the threshold size, elimination of the tumor can be achieved through repeated vaccine administrations with stepwise reduction of time periods between them. For the tumors of any size, the strategy of repeated administration of the virus-based vaccine that allows stabilizing the tumor size as per the start of the treatment was defined.</p> 2020-09-30T13:40:25+00:00 ##submission.copyrightStatement## The "Value at Risk" Principle in Hierarchical Game 2020-10-09T09:44:22+00:00 Mikhail Gorelov <p class="ASSAAbstract"><span lang="EN-US">A hierarchical game of two persons with random factors is considered. It is assumed that the top-level player has the right of the first move. It is believed that the lower level player at the time of decision making knows exactly the realization of the random factor and the choice of partner. And the top-level player at the time of decision making knows only a probabilistic measure on the set of values ​​of an uncertain factor. The principle of optimality is new: it is believed that a top-level player is ready to neglect some of the "unpleasant" events, the total probability of which is given, but otherwise he is careful. Under these assumptions, the maximum guaranteed result of the top-level player is calculated. The structure of strategies providing such a result is clarified. Two cases were investigated: a game with and without feedback. To solve the problem, an original definition of the maximum guaranteed result is proposed. It is equivalent to the classical definition, but is simpler. Using this technique, solving of the problem reduces to identical transformations of the formulas for predicate calculus. As a result of the solution, the optimal strategy and the set of "unpleasant" cases which are excluded from consideration search task is reduced to calculating multiple maximins on finite-dimensional spaces. In this case, the operation of calculating the expected value with respect to given probabilistic measure is considered to be "elementary". Models of this type can have different interpretations. One can use them for methodological justification of the principle of maximum guaranteed result. One can use them when solving risk management tasks. One can consider them as models for managing the "customer base" of the service company. The proposed method allows to study such models at a qualitative level, and in some cases to obtain quantitative results.</span></p> 2020-09-30T13:44:38+00:00 ##submission.copyrightStatement## Transformation of Regional Specialization Industries in the Conditions of New Technological Challenges 2020-10-09T09:44:22+00:00 Olga P. Smirnova Lidiya M. Averina Alena O. Ponomareva <p>The paper substantiates the significance of the problem of developing new branches of regional specialization. The mechanisms of transformation of regional specializations are investigated. The productive role of the concept of "smart specialization" for socio-economic and industrial development is noted. The empirical base of the study was Russia’s statistics for 2010-2018. The method of correlation and regression analysis identifies the influence of the way of using digital technologies on the development of traditional industries. The factors affecting the functioning of the industrial sector of Russia were identified. The current requirements and approaches to identifying the priorities of specialization of a region are given. As a result of the study, it was concluded that in order to transform traditional specialization industries and increase their competitiveness in modern conditions, their active interaction (integration and associated participation in production chains) with high-tech fast-growing industries is paramount. As expected, the introduction of new digital technologies will contribute to the growth of traditional industries, which will lead to an increase in their economic sustainability.</p> 2020-09-30T13:47:09+00:00 ##submission.copyrightStatement## Value Potentials in Innovation, Resources, Strategic Networks and Blocks 2020-10-09T09:44:22+00:00 Jeffrey Yi-Lin Forrest Sailau Baizakov Yohannes G. Haile Abel Gyan Yong Liu <p>The present globalizing world of business has been witnessing the emergence of unprecedented kinds of markets. These new kinds of markets post significant challenges to the world of learning and decision-making managers, entrepreneurs and alike. To confront these challenges, this paper investigates the potentials of value creation and value capture at the firm level from different perspectives. By employing systems methodology and the logical reasoning that parallels the one commonly used in mathematics and natural science, this paper establishes 16 formal propositions on value creation and value capture from the respective perspectives of market competition, innovation, resource, inter-organizational network, and direct association of sellers and buyers. In particular, this work points out (1) when innovation provides additional potentials for value creation; (2) when resources’ latent values can be practically made visible through value creation; (3) how markets’ mutual forbearance and relatively sustainably increased profitability are positively related, (4) why a firm’s systemic hole position offers advantages and profitability to the firm, (5) how a firm’s profitability is positively affected by its membership in a strategic block of increasing market influence; and (6) when a firm creates and maintains convenient platforms it will readily create and capture values. This paper concludes with some practically reliable general recommendations and a few topics and directions for future research.</p> 2020-09-30T15:31:57+00:00 ##submission.copyrightStatement## Delay Differential Equation Model of Gene Expression 2020-10-09T09:44:22+00:00 Amit Sharma Neeru Adlakha <p>In this study, a delay differential equation model of gene expression for both retroviruses and normal cell is proposed to study the dynamics of functional gene products. The model is categorised into two sub-models to understand the characteristics of a cell by incorporating time delays in the processes of gene expression. The first model which is for retroviruses, involves time delay in replication, transcription, reverse transcription and translation processes taking place in the cell, while in the second model which is for normal cell, the time delay in transcription and translation processes are incorporated. A numerical solution is obtained using semi-temporal data set. The impact of time delays on temporal concentration profile of DNA, mRNA and proteins have been analysed which gives better insight into the normal cell as well as retroviruses. Further, sensitivity analysis has been performed for both models to study the behaviour of gene expression in the cell. The results obtained from such models can be useful for biomedical applications.</p> 2020-09-30T15:33:50+00:00 ##submission.copyrightStatement## Classifying Amorphous Polymers for Membrane Technology Basing on Accessible Surface Area of Their Conformations 2020-10-09T09:44:22+00:00 Oleg Miloserdov <p>Almost 400 amorphous polymer materials used in membrane gas separation technology are clustered on the basis of the shape of their polymer chains conformations. Obtained clusters, which rely solely on the geometry of polymer chains and not on the chemical class (polyamides, polyacetylenes, etc.), are shown to discriminate polymers with respect to their transport properties, in particular, the coefficient of diffusion. The method proposed consists of several steps. Firstly, realistic conformations of large polymer macromolecules are constructed using the program code developed in the RDKit environment for Python. Then, polymer conformations are characterized by a curve that relates the “accessible surface area” (i.e., the contact surface between the spherical model of a macromolecule and a spherical “probe”) to the radius of this probe, and also seven similar curves, which relate the polarized (neutral, positively or negatively charged, etc.) accessible surface area to the radius of the spherical probe that represents the variety of penetrant gases. An improved algorithm for surface area calculation maps out the outer surface of the macromolecule to eliminate its influence. The curves are averaged between ten polymer conformations to obtain more robust figures. Finally, agglomerative clustering is used to separate different polymers in the space of these curves that align their accessible-surface-area-related quantities against the probe radius. The proposed classification of polymers can be used to develop more precise predictive models of polymers’ transport properties for the theory-guided and computer-aided materials design.</p> 2020-09-30T15:36:32+00:00 ##submission.copyrightStatement## Estimating the Response Time of a Cloud Computing System with the Help of Neural Networks 2020-10-09T09:44:22+00:00 Anastasia V. Gorbunova Vladimir M. Vishnevsky <p>The article presents a new approach to assessing the average response time of a cloud computing system and its dispersion. A fork-join system or a system with request splitting was chosen as a queuing model, and artificial neural networks were used as a method for estimating a variable of interest. The analysis showed that the estimates obtained were more accurate than those previously known. Besides, the proposed approach allows expanding the analysis of the cloud system to the case of a model with a non-Poisson input stream and non-exponential service time, as well as obtaining estimates for a larger number of performance indicators of the cloud system, which was not previously possible.</p> 2020-09-30T15:39:04+00:00 ##submission.copyrightStatement## Control, Activity, Personality 2020-10-09T09:44:22+00:00 Dmitry Novikov <p>The paper presents the view of a control theoretician on the theories of personality and activity, in search of their results necessary for the formulation and solution of control problems for systems with active elements (man). The constructions proposed below can be treated as an “interface” that establishes a correspondence between the approaches and results of personality psychology, control methodology, and control science.</p> <p>The paper is intended for control theoreticians, who may read it for getting initial ideas about the theories of personality and activity as well as about their connection with control of social and organizational-technical systems. In turn, psychologists may observe not only the prospects of using their results in the above-mentioned branches of control theory, but also a number of new challenges.</p> 2020-09-30T15:40:45+00:00 ##submission.copyrightStatement## Plasma Control in Tokamaks 2020-10-09T09:44:22+00:00 Yuri Vladimirovich Mitrishkin Nikolay Mikhailovich Kartsev Artem Evgenyevich Konkov Mikhail Ivanovich Patrov <p class="Abstract"><span lang="EN-US" style="font-weight: normal;">Experimental testing of ITER scenarios on the DIII-D (US) and WEST (France) tokamaks, approaches for simulation and realization of ITER plasma control systems, the preparation of ITER plasma control systems for starting and exploitation are presented. The roadmaps that are known in Europe for the development and creation of the first fusion power plant DEMO (the next step after ITER) are reported. These maps show two directions of DEMO development: (i) based on conventional tokamaks with relatively large aspect ratio and (ii) based on spherical tokamaks of module type giving a chance to noticeably reduce the time needed to create the DEMO and to get cheap competitive electrical energy. The basic trends in the design of DEMO poloidal systems, as well as the initial version of the DEMO plasma vertical position control system, are given.</span></p> 2020-09-30T15:42:43+00:00 ##submission.copyrightStatement## Control Model of the Floodplain Territories Structure 2020-10-09T09:44:22+00:00 Alexander A. Voronin Alexander V. Khoperskov Inessa I. Isaeva Anna Yu. Klikunova <p>We have developed a model of an integrated hydrological, environmental and socio-economic structure of the floodplain area, which is the subject of strategic control based on the observational data, the results of hydrodynamic and geoinformation modeling. The state assessment of each structural element is determined by the degree of correspondence between the hydrological type and the socio-economic type of the floodplain area.&nbsp; The goal of control is to implement a territorial structure that maximizes the value of the aggregated criterion for a stable state of the system. The control mechanism is a complex of hydraulic engineering projects (multiproject) in various channels in the floodplain area.&nbsp; The simulations results of the implementation of the sustainable development strategy of the environmental and socio-economic system of the Volga-Akhtuba floodplain northern part are presented.</p> 2020-09-30T15:44:35+00:00 ##submission.copyrightStatement## A Differential Stackelberg Game Theoretic Model of the Promotion of Innovations in Universities 2020-10-09T09:44:22+00:00 Mukharbek Malsagov Gennady Ougolnitsky Anatoly Usov <p>A two-level dynamical game theoretic model "federal state - universities" in open-loop strategies is built and investigated. A refinement of the electronic learning courses, and their differentiation using modern methods of information technologies made by competing a la Cournot universities (agents) are treated as innovative investments. The algorithms of building Nash (in the non-coalitional game of agents) and Stackelberg (in the hierarchical game of the Principal with the grand coalition of agents) equilibria are proposed and implemented. For the solution of the respective dynamic control problems the Pontryagin maximum principle and simulation modeling are used. A comprehensive analysis of the received results is given.</p> 2020-09-30T15:46:56+00:00 ##submission.copyrightStatement##